Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.44 |
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 10/20 | 0.38 |
| ▸ | JAK1 | P23458 | 9/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28887531 | 0.91 | JAK3 (0.39) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL29522964 | 0.91 | JAK3 (0.39) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL29523014 | 0.91 | IGF1R (0.40) | JAK3IGF1RJAK2JAK1PTK2 | |
| SCHEMBL28887519 | 0.87 | JAK3 (0.46) | JAK3IGF1RJAK2JAK1PTK2 | |
| SCHEMBL28887524 | 0.87 | JAK3 (0.59) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL28887516 | 0.87 | JAK3 (0.50) | JAK3IGF1RJAK2JAK1 | |
| SCHEMBL28887556 | 0.87 | JAK1 (0.43) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL28887603 | 0.85 | JAK2 (0.51) | JAK3IGF1RJAK2JAK1TYK2 | |
| SCHEMBL28887601 | 0.84 | JAK1 (0.55) | JAK3IGF1RJAK2JAK1TYK2 | |
| SCHEMBL28887607 | 0.79 | HTT (0.41) | JAK3IGF1RJAK2JAK1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | claimed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | disclosed |