Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.55 |
| ▸ | JAK2 | O60674 | 7/20 | 0.55 |
| ▸ | JAK3 | P52333 | 11/20 | 0.45 |
| ▸ | TYK2 | P29597 | 7/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28887556 | 0.90 | JAK1 (0.43) | JAK1JAK2JAK3TYK2TTK | |
| SCHEMBL28887563 | 0.90 | JAK1 (0.44) | JAK1JAK2JAK3TYK2IKBKE | |
| SCHEMBL28887603 | 0.88 | JAK2 (0.51) | JAK1JAK2JAK3TYK2TTK | |
| SCHEMBL29522964 | 0.85 | JAK3 (0.39) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL28887531 | 0.85 | JAK3 (0.39) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL28887532 | 0.85 | JAK3 (0.49) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL28887542 | 0.84 | JAK3 (0.53) | JAK1JAK2JAK3TYK2AURKA | |
| SCHEMBL29523539 | 0.84 | JAK3 (0.44) | JAK1JAK2JAK3TYK2IGF1R | |
| SCHEMBL28887604 | 0.80 | JAK1 (0.38) | JAK1JAK2JAK3TYK2IKBKE | |
| SCHEMBL28887507 | 0.78 | JAK2 (0.41) | JAK1JAK2JAK3TYK2TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | claimed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | claimed |
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | disclosed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | disclosed |