Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9571667 | 0.84 | RAB9A (0.45) | RAB9ANAMPTGPR119NOTUMALDH1A1 | |
| SCHEMBL31554105 | 0.83 | NOTUM (0.48) | RAB9ANAMPTGPR119NOTUMALDH1A1 | |
| SCHEMBL479924 | 0.83 | NOTUM (0.48) | RAB9ANAMPTGPR119NOTUMALDH1A1 | |
| SCHEMBL1760110 | 0.82 | RAB9A (0.43) | RAB9ANAMPTGPR119KCNA5NOTUM | |
| SCHEMBL9571669 | 0.81 | RAB9A (0.42) | RAB9ANAMPTGPR119KCNA5NOTUM | |
| SCHEMBL1529415 | 0.81 | PTGIR (0.49) | RAB9ANAMPTGPR119KCNA5NOTUM | |
| SCHEMBL28609083 | 0.79 | HTT (0.51) | RAB9ANAMPTGPR119KCNA5NOTUM | |
| SCHEMBL28387858 | 0.78 | RAB9A (0.34) | RAB9ANAMPTGPR119 | |
| SCHEMBL30665133 | 0.77 | GPR119 (0.45) | RAB9ANAMPTGPR119CYP3A4 | |
| SCHEMBL6615498 | 0.77 | HTT (0.43) | RAB9ANAMPTGPR119KCNA5NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111094267-B | Sulfonyl-substituted bicyclic compounds as ROR gamma inhibitors | 正大天晴药业集团股份有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-111094267-A | Sulfonyl-substituted bicyclic compounds as ROR gamma inhibitors | 正大天晴药业集团股份有限公司 | 2020-05-01 | — | — | CN | disclosed |