Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941839 | 0.90 | PHGDH (0.41) | MEN1KMT2AADRB2HTTRAB9A | |
| SCHEMBL28889250 | 0.89 | MEN1 (0.44) | MEN1KMT2AADRB2LMNAPOLB | |
| SCHEMBL29893755 | 0.89 | MEN1 (0.44) | MEN1KMT2AADRB2LMNAPOLB | |
| SCHEMBL29941697 | 0.89 | MEN1 (0.49) | MEN1KMT2AADRB2POLBMAPT | |
| SCHEMBL29893656 | 0.88 | MEN1 (0.43) | MEN1KMT2AADRB2LMNAPOLB | |
| SCHEMBL28889304 | 0.88 | MEN1 (0.43) | MEN1KMT2AADRB2LMNAPOLB | |
| SCHEMBL28889213 | 0.88 | ADRB2 (0.41) | MEN1KMT2AADRB2PSEN1PSEN2 | |
| SCHEMBL28889179 | 0.85 | KMT2A (0.41) | MEN1KMT2AADRB2HTTRAB9A | |
| SCHEMBL28889194 | 0.85 | ADRB2 (0.37) | MEN1KMT2AADRB2HTTRAB9A | |
| SCHEMBL28889226 | 0.82 | AURKA (0.42) | MEN1KMT2AADRB2HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |