Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 10/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL2889020 | 1.00 | KCNA5 (0.44) | KCNA5ABCB1OPRM1IDO1ALDH1A1 | |
| Fumaric Acid SCHEMBL2889022 | 1.00 | KCNA5 (0.44) | KCNA5ABCB1OPRM1IDO1ALDH1A1 | |
| SCHEMBL2889459 | 0.94 | KCNA5 (0.47) | KCNA5ABCB1OPRM1IDO1 | |
| SCHEMBL2889456 | 0.94 | KCNA5 (0.47) | KCNA5ABCB1OPRM1IDO1 | |
| Fumaric Acid SCHEMBL2891986 | 0.90 | KCNA5 (0.44) | KCNA5ABCB1IDO1ALDH1A1TAAR1 | |
| Maleic Acid SCHEMBL2891985 | 0.90 | KCNA5 (0.44) | KCNA5ABCB1IDO1ALDH1A1TAAR1 | |
| SCHEMBL2887577 | 0.86 | KCNA5 (0.48) | KCNA5ABCB1IDO1 | |
| Hydrochloric Acid SCHEMBL2891525 | 0.85 | KCNA5 (0.47) | KCNA5ABCB1IDO1 | |
| SCHEMBL2883892 | 0.83 | KCNA5 (0.46) | KCNA5ABCB1IDO1 | |
| SCHEMBL2887648 | 0.83 | KCNA5 (0.50) | KCNA5ABCB1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781483-B2 | Benzopyran compound | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-08-24 | — | — | US | disclosed |