Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10247167 | 0.83 | ALDH1A1 (0.44) | KMT2AMEN1GSK3BRAB9AALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28935110 | 0.81 | ALDH1A1 (0.43) | KMT2AMEN1GSK3BRAB9AALDH1A1 | |
| Bromide SCHEMBL27527965 | 0.81 | ALDH1A1 (0.43) | KMT2AMEN1GSK3BNPC1RAB9A | |
| Bromide SCHEMBL27527963 | 0.79 | HDAC3 (0.41) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL27542998 | 0.77 | ALDH1A1 (0.39) | KMT2AMEN1GSK3BRAB9AALDH1A1 | |
| Bromide SCHEMBL6073932 | 0.76 | KMT2A (0.54) | KMT2AMEN1GSK3BNPC1RAB9A | |
| Iodide SCHEMBL28394234 | 0.74 | PLOD2 (0.47) | KMT2AMEN1ALDH1A1KDM4ESRC | |
| SCHEMBL10531146 | 0.72 | KMT2A (0.50) | KMT2AMEN1GSK3BNPC1RAB9A | |
| Bromide SCHEMBL10529208 | 0.71 | KMT2A (0.49) | KMT2AMEN1GSK3BNPC1RAB9A | |
| Bromide SCHEMBL10526792 | 0.71 | KMT2A (0.56) | KMT2AMEN1GSK3BNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111194232-B | Nanoscale metal-organic layer and metal-organic nanosheet | 芝加哥大学 | 2023-01-31 | — | — | CN | disclosed |
| CN-111194232-A | Nanoscale metal-organic layers and metal-organic nanoplatelets for X-ray induced photodynamic therapy, radiotherapy, photodynamic therapy, chemotherapy, immunotherapy and any combination thereof | 芝加哥大学 | 2020-05-22 | — | — | CN | disclosed |