Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28401226 | 0.88 | DPP4 (0.47) | SMN1; SMN2TSHRMEN1KMT2ADPP4 | |
| SCHEMBL28401228 | 0.88 | DPP4 (0.47) | SMN1; SMN2TSHRMEN1KMT2ADPP4 | |
| SCHEMBL23891810 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2TSHRKDM4EDPP4LMNA | |
| SCHEMBL23878366 | 0.82 | HTT (0.43) | SMN1; SMN2TSHRKDM4EMEN1KMT2A | |
| SCHEMBL28407065 | 0.81 | NPC1 (0.50) | SMN1; SMN2TSHRKDM4EMEN1KMT2A | |
| SCHEMBL28398674 | 0.80 | CES2 (0.38) | TSHRDPP4MAPTLMNATAS1R3 | |
| SCHEMBL28398673 | 0.80 | CES2 (0.38) | TSHRDPP4MAPTLMNATAS1R3 | |
| SCHEMBL7436605 | 0.74 | HPGD (0.52) | SMN1; SMN2TSHRKDM4EMEN1KMT2A | |
| SCHEMBL28407079 | 0.74 | ACKR3 (0.44) | — | |
| SCHEMBL28407080 | 0.74 | ACKR3 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111217802-B | Histone acetylase p300 inhibitor and application thereof | 海创药业股份有限公司 | 2021-10-08 | — | — | CN | disclosed |
| CN-111217802-A | Histone acetylase p300 inhibitor and application thereof | 成都海创药业有限公司 | 2020-06-02 | — | — | CN | disclosed |