Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28890488 | 0.87 | KCNN3 (0.54) | TLR8TLR7KCNN3CRHR1 | |
| SCHEMBL29236251 | 0.87 | KCNN3 (0.54) | TLR8TLR7KCNN3CRHR1 | |
| SCHEMBL28890492 | 0.67 | TLR8 (0.67) | TLR8TLR7KCNH2 | |
| SCHEMBL29236195 | 0.67 | TLR8 (0.67) | TLR8TLR7KCNH2 | |
| SCHEMBL28890448 | 0.67 | TLR8 (0.67) | TLR8TLR7KCNH2 | |
| SCHEMBL28890489 | 0.67 | TLR8 (0.50) | TLR8TLR7KCNH2 | |
| SCHEMBL23472394 | 0.66 | TLR8 (0.55) | TLR8TLR7CDK9CCNT1KCNH2 | |
| SCHEMBL22958982 | 0.65 | KCNH2 (0.60) | TLR8TLR7KCNH2 | |
| SCHEMBL29956995 | 0.64 | TLR8 (0.68) | TLR8TLR7KCNH2 | |
| SCHEMBL28890540 | 0.64 | TLR8 (0.68) | TLR8TLR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115362155-B | Arylamine derivative, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-115362155-A | Arylamine derivatives, and preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2022-11-18 | — | — | CN | disclosed |