Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.73 |
| ▸ | ATR | Q13535 | 3/20 | 0.64 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886450 | 0.88 | MCHR1 (0.58) | MCHR1ATRL3MBTL3 | |
| SCHEMBL2885651 | 0.85 | ATR (0.57) | MCHR1ATRL3MBTL3HRH3 | |
| SCHEMBL12529204 | 0.84 | MCHR1 (1.00) | MCHR1 | |
| SCHEMBL2885755 | 0.83 | HDAC3 (0.57) | MCHR1ATRL3MBTL3 | |
| SCHEMBL10293555 | 0.82 | L3MBTL3 (0.69) | ATRL3MBTL3HRH3 | |
| SCHEMBL10293598 | 0.82 | L3MBTL3 (0.69) | ATRL3MBTL3HRH3 | |
| SCHEMBL2889846 | 0.82 | GHSR (0.55) | MCHR1ATR | |
| SCHEMBL2885719 | 0.81 | ATR (0.55) | MCHR1ATRL3MBTL3HRH3 | |
| SCHEMBL18177421 | 0.80 | ATR (0.71) | MCHR1ATRHRH3 | |
| SCHEMBL16420738 | 0.80 | ATR (0.71) | MCHR1ATRHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270440-A1 | N-benzoyl- and N-benzylpyrrolidin-3-ylamines as histamine-3 antagonists | WYETH (US) | 2007-11-22 | — | — | US | claimed |
| US-7842715-B2 | N-benzoyl- and N-benzylpyrrolidin-3-ylamines as histamine-3 antagonists | WYETH LLC (US) | 2010-11-30 | — | — | US | disclosed |
| US-20070270440-A1 | N-benzoyl- and N-benzylpyrrolidin-3-ylamines as histamine-3 antagonists | WYETH (US) | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270440-A1 | N-benzoyl- and N-benzylpyrrolidin-3-ylamines as histamine-3 antagonists | HRH4, HRH3, HRH2 | MCHR1 184/4885ATR 4689/4885L3MBTL3 2436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.