Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 6/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LIG1 | P18858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 2/20 | 0.35 |
| ▸ | RARG | P13631 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 2/20 | 0.35 |
| ▸ | RXRG | P48443 | 2/20 | 0.35 |
| ▸ | RARA | P10276 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16057270 | 1.00 | DAO (0.46) | DAOPKMLIG1KMT2AMEN1 | |
| SCHEMBL17475242 | 1.00 | DAO (0.46) | DAOPKMLIG1KMT2AMEN1 | |
| SCHEMBL16088586 | 0.83 | NPSR1 (0.45) | PKMKMT2AMEN1POLBRAB9A | |
| SCHEMBL16401728 | 0.83 | NPSR1 (0.45) | PKMKMT2AMEN1POLBRAB9A | |
| SCHEMBL15550265 | 0.83 | NPSR1 (0.45) | PKMKMT2AMEN1POLBRAB9A | |
| SCHEMBL22380001 | 0.82 | DAO (0.52) | DAOPKMLIG1KMT2AMEN1 | |
| SCHEMBL10023944 | 0.76 | DAO (0.50) | DAOPKMLIG1KMT2AMEN1 | |
| SCHEMBL8435188 | 0.73 | ALOX5 (0.48) | DAOKMT2AMEN1POLBRAB9A | |
| SCHEMBL8435184 | 0.73 | ALOX5 (0.48) | DAOKMT2AMEN1POLBRAB9A | |
| SCHEMBL8437696 | 0.73 | ALOX5 (0.48) | DAOKMT2AMEN1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107802623-B | Difluorolactam compositions for EP 4-mediated bone-related diseases and disorders | 开曼化学股份有限公司 | 2020-10-30 | — | — | CN | disclosed |
| CN-106748951-B | Difluorolactam compounds as EP4 receptor selective agonists for use in the treatment of EP4 mediated diseases and conditions | 开曼化学股份有限公司 | 2020-07-24 | — | — | CN | disclosed |