Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.52 |
| ▸ | WDR5 | P61964 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18837900 | 0.84 | MAPT (0.58) | POLBMAPK1KMT2AMAPTMEN1 | |
| SCHEMBL10355 | 0.83 | KMT2A (0.69) | POLBKMT2AMAPTMEN1BLM | |
| SCHEMBL9056834 | 0.82 | CRBN (0.61) | POLBCRBNMAPTHDAC8HDAC6 | |
| SCHEMBL2031327 | 0.82 | CA12 (0.62) | POLBMAPK1KMT2AMAPTMEN1 | |
| SCHEMBL13702375 | 0.82 | HDAC8 (0.68) | CRBNHDAC8HDAC6HDAC2CDK8 | |
| SCHEMBL629211 | 0.81 | TP53 (0.67) | POLBMAPK1KMT2AMAPTMEN1 | |
| SCHEMBL8686215 | 0.81 | TP53 (0.67) | POLBMAPK1KMT2AMAPTMEN1 | |
| SCHEMBL723332 | 0.81 | HDAC8 (0.70) | POLBCRBNMAPTHDAC8HDAC6 | |
| SCHEMBL3725488 | 0.80 | TSHR (0.68) | POLBMAPK1HDAC2 | |
| SCHEMBL1302830 | 0.80 | ALDH1A1 (0.68) | POLBMAPK1ALOX5HDAC2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117447395-A | Method for preparing sorafenib key intermediate by utilizing micro-channel continuous flow | 山东安弘制药有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-108409648-B | Preparation method of sorafenib tosylate related intermediate | 盐城师范学院 | 2020-06-09 | — | — | CN | disclosed |