Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL223451 | 0.94 | MAPT (0.63) | MAPTL3MBTL1POLBMAPK1KMT2A | |
| SCHEMBL3047151 | 0.85 | MAPT (0.57) | MAPTL3MBTL1POLBMAPK1KMT2A | |
| SCHEMBL28895007 | 0.84 | POLB (0.53) | MAPTPOLBMAPK1KMT2AMEN1 | |
| SCHEMBL27815181 | 0.83 | MAPT (0.67) | MAPTL3MBTL1POLBMAPK1KMT2A | |
| SCHEMBL16198923 | 0.82 | HDAC6 (0.70) | CA2TSHRHDAC1HDAC2 | |
| SCHEMBL14115137 | 0.82 | HDAC6 (0.70) | CA2TSHRHDAC1HDAC2 | |
| SCHEMBL8525187 | 0.82 | POLB (0.57) | MAPTPOLBMAPK1KMT2AMEN1 | |
| Diphenylether SCHEMBL6868881 | 0.81 | FFAR1 (0.62) | MAPTL3MBTL1POLBMAPK1KMT2A | |
| SCHEMBL16367722 | 0.81 | KMT2A (0.76) | MAPTPOLBMAPK1KMT2AMEN1 | |
| SCHEMBL11060793 | 0.80 | KDM4E (0.68) | MAPTL3MBTL1POLBMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10611747-B2 | Pyrone based compounds for treating bacterial infections | FORGE THERAPEUTICS, INC. (US) | 2020-04-07 | — | — | US | disclosed |
| US-20180319761-A1 | PYRONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | BLACKSMITH MEDICINES, INC. | 2018-11-08 | — | — | US | disclosed |
| EP-3374355-A1 | PYRONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | Forge Therapeutics, Inc. (US) | 2018-09-19 | — | — | EP | disclosed |
| WO-2017083434-A1 | PYRONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | FORGE THERAPEUTICS, INC. (US) | 2017-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10611747-B2 | Pyrone based compounds for treating bacterial infections | PYCARD, GSDMD, NOD2 | MAPT 2970/4885L3MBTL1 4040/4885POLB 1175/4885 |
| US-20180319761-A1 | PYRONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | PYCARD, GSDMD, NOD2 | MAPT 2970/4885L3MBTL1 4040/4885POLB 1175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.