SCHEMBL28895268

SCHEMBL28895268

CCOC(=O)c1ccc2c(c1)[nH]c(=O)c1ccc(Br)n12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.55
MAPT P10636 3/20 0.55
RAB9A P51151 3/20 0.55
PPARG P37231 1/20 0.55
NCOA2 Q15596 1/20 0.55
NCOA1 Q15788 1/20 0.55
KDM4E B2RXH2 5/20 0.46
HSD17B10 Q99714 4/20 0.46
MAPK1 P28482 3/20 0.46
POLB P06746 2/20 0.46
HPGD P15428 2/20 0.46
PARP1 P09874 1/20 0.46
SIRT2 Q8IXJ6 2/20 0.46
HCRTR1 O43613 2/20 0.45
MAT2A P31153 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29965925 1.00 ALDH1A1 (0.55) ALDH1A1MAPTRAB9APPARGNCOA2
SCHEMBL28895087 0.80 PARP1 (0.46) ALDH1A1MAPTKDM4EPARP1SIRT2
SCHEMBL3786255 0.78 PARP1 (0.59) ALDH1A1MAPTRAB9APPARGNCOA2
SCHEMBL29965297 0.78 PARP1 (0.59) ALDH1A1MAPTRAB9APPARGNCOA2
SCHEMBL3589280 0.78 PDE9A (0.69) ALDH1A1MAPTRAB9APPARGNCOA2
SCHEMBL3596617 0.77 PDE2A (0.49) ALDH1A1MAPTRAB9APPARGNCOA2
SCHEMBL3594437 0.77 PDE9A (0.56) ALDH1A1MAPTRAB9APPARGNCOA2
SCHEMBL1459044 0.76 ALDH1A1 (0.61) ALDH1A1MAPTRAB9APPARGNCOA2
SCHEMBL27541312 0.76 ALDH1A1 (0.61) ALDH1A1MAPTRAB9APPARGNCOA2
SCHEMBL31377412 0.74 TP53 (0.48) ALDH1A1MAPTRAB9APPARGNCOA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115368362-A Quinoxalinone derivatives as BTK inhibitors and application thereof 华东理工大学 2022-11-22 CN disclosed