Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.53 |
| ▸ | MGAM | O43451 | 5/20 | 0.53 |
| ▸ | SI | P14410 | 5/20 | 0.53 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496645 | 0.84 | GAA (0.51) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL5691075 | 0.84 | AMY1A (0.52) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL5827764 | 0.83 | NPC1 (0.63) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL15932980 | 0.82 | MGAM (0.67) | GAAMGAMSIMGAM2KDM4E | |
| SCHEMBL14125145 | 0.82 | GAA (0.56) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL1704782 | 0.81 | NPC1 (0.47) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL27700749 | 0.81 | ESR2 (0.59) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL14363397 | 0.81 | MGAM (0.53) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL23969971 | 0.80 | MGAM (0.51) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL18593397 | 0.80 | ERN1 (0.56) | GAAMGAMSIMGAM2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849037-B | Tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prevention of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2020-04-17 | — | — | CN | disclosed |