Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SI | P14410 | 1/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496645 | 0.84 | GAA (0.51) | NPC1RAB9ATSHRMAPTMGAM | |
| SCHEMBL10039354 | 0.82 | NPC1 (0.48) | NPC1RAB9ATSHRMAPTMGAM | |
| SCHEMBL29697785 | 0.82 | MAPT (0.56) | NPC1RAB9ATSHRMAPTGAA | |
| SCHEMBL14125145 | 0.82 | GAA (0.56) | NPC1RAB9ATSHRMAPTMGAM | |
| SCHEMBL12326165 | 0.82 | MAPT (0.56) | NPC1RAB9ATSHRMAPTGAA | |
| SCHEMBL811943 | 0.82 | MAPK1 (0.65) | TSHRMAPTALDH1A1MAPK1TDP1 | |
| SCHEMBL29697819 | 0.82 | MAPK1 (0.65) | TSHRMAPTALDH1A1MAPK1TDP1 | |
| SCHEMBL29634026 | 0.81 | NPC1 (0.54) | NPC1RAB9ATSHRMAPTMGAM | |
| SCHEMBL28895392 | 0.81 | GAA (0.53) | NPC1RAB9ATSHRMAPTMGAM | |
| SCHEMBL5691075 | 0.80 | AMY1A (0.52) | NPC1RAB9ATSHRMAPTMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3364957-B1 | IMPROVED SYNTHESIS OF HONOKIOL | COLGATE PALMOLIVE CO (US) | 2020-12-09 | — | — | EP | disclosed |
| EP-3364957-B1 | IMPROVED SYNTHESIS OF HONOKIOL | COLGATE PALMOLIVE CO (US) | 2020-12-09 | — | — | EP | disclosed |
| EP-3364957-A1 | IMPROVED SYNTHESIS OF HONOKIOL | Colgate-Palmolive Company (US) | 2018-08-29 | — | — | EP | disclosed |
| US-10053406-B2 | Synthesis of honokiol | COLGATE-PALMOLIVE COMPANY (US) | 2018-08-21 | — | — | US | disclosed |
| WO-2017070568-A1 | IMPROVED SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY (US) | 2017-04-27 | — | — | WO | disclosed |
| WO-2017070568-A1 | IMPROVED SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY (US) | 2017-04-27 | — | — | WO | disclosed |
| US-20170113989-A1 | SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY | 2017-04-27 | — | — | US | disclosed |
| US-20170113989-A1 | SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY | 2017-04-27 | — | — | US | disclosed |
| US-20170113989-A1 | SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY | 2017-04-27 | — | — | US | disclosed |
| US-8425881-B2 | Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods | COLGATE-PALMOLIVE COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-8425881-B2 | Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods | COLGATE-PALMOLIVE COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-8425881-B2 | Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods | COLGATE-PALMOLIVE COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| EP-1863432-B1 | Antiplaque 3',5-disubstituted 2,4'-dihydroxybiphenyl compounds and toothpaste composition | COLGATE PALMOLIVE CO (US) | 2012-04-18 | — | — | EP | disclosed |
| EP-1863432-A1 | ANTIBACTERIAL 3',5-DISUBSTITUTED 2,4'-DIHYDROXYBIPHENYL COMPOUNDS, DERIVATIVES AND RELATED METHODS | Colgate-Palmolive Company (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006101818-A1 | ANTIBACTERIAL 3',5-DISUBSTITUTED 2,4'-DIHYDROXYBIPHENYL COMPOUNDS, DERIVATIVES AND RELATED METHODS | COLGATE-PALMOLIVE COMPANY (US) | 2006-09-28 | — | — | WO | disclosed |
| US-20060210489-A1 | Antibacterial 3',5-disubstituted 2,4'-dihydroxybiphenyl compounds, derivatives and related methods | COLGATE-PALMOLIVE | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170113989-A1 | SYNTHESIS OF HONOKIOL | UGT2B7, UGT1A7, DHCR7 | NPC1 2039/4885RAB9A 4724/4885TSHR 3230/4885 |
| US-10053406-B2 | Synthesis of honokiol | UGT2B7, UGT1A7, DHCR7 | NPC1 2039/4885RAB9A 4724/4885TSHR 3230/4885 |
| US-20060210489-A1 | Antibacterial 3',5-disubstituted 2,4'-dihydroxybiphenyl compounds, derivatives and related methods | DRD4, QDPR, TPD52L2 | NPC1 162/4885RAB9A 997/4885TSHR 3698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.