Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28959834 | 0.85 | S1PR2 (0.61) | KDM4EKMT2AMEN1ATMMAPK1 | |
| SCHEMBL4143308 | 0.81 | KMT2A (0.56) | KDM4EKMT2AMEN1NPSR1GLA | |
| SCHEMBL9832496 | 0.79 | KDM4E (0.58) | KDM4EKMT2AMEN1ATMCHRM2 | |
| SCHEMBL1238474 | 0.79 | GLA (0.54) | KMT2AGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL1237067 | 0.79 | GLA (0.54) | KMT2AGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL28896647 | 0.79 | EPHX2 (0.50) | KDM4EKMT2AMEN1GLAEPHX2 | |
| SCHEMBL6268278 | 0.78 | CHRM2 (0.60) | KDM4EKMT2AMEN1ATMMAPK1 | |
| SCHEMBL2241047 | 0.78 | LDHA (0.57) | KDM4EKMT2AMEN1NPSR1GLA | |
| SCHEMBL537492 | 0.77 | KDM4E (0.62) | KDM4EKMT2AMEN1ATMCHRM2 | |
| SCHEMBL3214303 | 0.76 | CHRM2 (0.66) | KMT2AMEN1ATMMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |