Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896621 | 0.88 | HTT (0.38) | HTTMAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL28896313 | 0.82 | APLNR (0.39) | HTTMAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL28896560 | 0.74 | ALDH1A1 (0.35) | HTTMAPTALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL28896301 | 0.72 | HTT (0.40) | HTTMAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL28896204 | 0.69 | APLNR (0.40) | HTTMAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL17271883 | 0.69 | HTT (0.47) | HTTPOLBALDH1A1SMN1; SMN2PYCR1 | |
| SCHEMBL28595152 | 0.69 | HTT (0.50) | HTTPOLBALDH1A1SMN1; SMN2PYCR1 | |
| SCHEMBL14438327 | 0.68 | APLNR (0.55) | HTTMAPTALDH1A1SMN1; SMN2PYCR1 | |
| SCHEMBL6565389 | 0.67 | APLNR (0.46) | HTTMAPTALDH1A1SMN1; SMN2PYCR1 | |
| SCHEMBL25402687 | 0.67 | HTT (0.45) | HTTMAPTPOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |