Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572340 | 0.83 | MAPT (0.51) | MAPTTP53LMNAHDAC8HDAC6 | |
| SCHEMBL28899183 | 0.82 | MAPT (0.49) | MAPTTP53LMNAHDAC8HDAC6 | |
| SCHEMBL30095464 | 0.82 | MAPT (0.49) | MAPTTP53LMNAHDAC8HDAC6 | |
| SCHEMBL2332782 | 0.80 | LMNA (0.49) | MAPTTP53LMNAHDAC8HDAC6 | |
| SCHEMBL1571627 | 0.78 | MAPT (0.52) | MAPTTP53LMNAHDAC8HDAC6 | |
| SCHEMBL28899173 | 0.77 | MAPT (0.45) | MAPTTP53LMNAHDAC8HDAC6 | |
| SCHEMBL25368386 | 0.75 | HDAC3 (0.51) | MAPTTP53LMNAHDAC6HDAC3 | |
| SCHEMBL30362894 | 0.75 | HDAC3 (0.51) | MAPTTP53LMNAHDAC6HDAC3 | |
| SCHEMBL15804000 | 0.75 | RECQL (0.61) | MAPTTP53LMNAHDAC8HDAC6 | |
| SCHEMBL1411852 | 0.74 | LMNA (0.54) | MAPTTP53LMNAHDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109456308-B | Heterocyclic compounds as ASK inhibitors and their use | 南京圣和药业股份有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-109456308-A | Heterocyclic compound and its application as ASK inhibitor | 南京圣和药业股份有限公司 | 2019-03-12 | — | — | CN | disclosed |