Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 6/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21410360 | 0.85 | BCL6 (0.42) | PIN1CDK19ALKEGFRLRRK2 | |
| SCHEMBL1774193 | 0.76 | IGF1R (0.68) | MEN1KMT2AIGF1RPIN1CDK19 | |
| SCHEMBL5260245 | 0.73 | PTK2 (0.51) | MEN1KMT2AIGF1RCDK2KDR | |
| SCHEMBL24260666 | 0.72 | IGF1R (0.55) | MEN1KMT2AIGF1RCDK19ALK | |
| SCHEMBL30833802 | 0.72 | IGF1R (0.55) | MEN1KMT2AIGF1RCDK19ALK | |
| SCHEMBL17544687 | 0.72 | IGF1R (0.55) | MEN1KMT2AIGF1RCDK19ALK | |
| SCHEMBL3407903 | 0.71 | IGF1R (0.41) | MEN1KMT2AIGF1RCDK19ALK | |
| SCHEMBL4025891 | 0.70 | IGF1R (0.52) | MEN1KMT2AIGF1RCDK19ALK | |
| SCHEMBL30833716 | 0.70 | IGF1R (0.52) | MEN1KMT2AIGF1RCDK19ALK | |
| SCHEMBL14240127 | 0.70 | IGF1R (0.52) | MEN1KMT2AIGF1RPIN1CDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-117222637-A | EGFR degrading agents and related methods of use | 百济神州有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-115260237-A | EGFR-degrading agents and related methods of use | 百济神州(北京)生物科技有限公司 | 2022-11-01 | — | — | CN | disclosed |