Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 14/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29594294 | 1.00 | MAPK14 (0.39) | MAPK14CRHR1L3MBTL1 | |
| SCHEMBL1060285 | 0.82 | CRHR1 (0.40) | MAPK14CRHR1 | |
| SCHEMBL28461868 | 0.81 | MAPK14 (0.41) | MAPK14L3MBTL1 | |
| SCHEMBL29593302 | 0.81 | MAPK14 (0.41) | MAPK14L3MBTL1 | |
| SCHEMBL29594818 | 0.78 | CRHR1 (0.35) | CRHR1 | |
| SCHEMBL28461877 | 0.78 | CRHR1 (0.35) | CRHR1 | |
| SCHEMBL29593632 | 0.78 | CRHR1 (0.37) | MAPK14CRHR1 | |
| SCHEMBL28459802 | 0.78 | CRHR1 (0.37) | MAPK14CRHR1 | |
| SCHEMBL27826678 | 0.77 | MAPK14 (0.37) | MAPK14 | |
| SCHEMBL29593556 | 0.74 | GRIA4 (0.37) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-111601593-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2020-08-28 | — | — | CN | disclosed |