Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 3/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31496906 | 0.83 | KDM4E (0.38) | KDM4EGAASMN1; SMN2MAOAMAOB | |
| SCHEMBL28900724 | 0.76 | PARP10 (0.39) | — | |
| SCHEMBL23723789 | 0.75 | KDM4E (0.37) | KDM4EGAASMN1; SMN2MAOAMAOB | |
| SCHEMBL23723787 | 0.75 | KDM4E (0.37) | KDM4EGAASMN1; SMN2MAOAMAOB | |
| SCHEMBL28900650 | 0.74 | — | — | |
| SCHEMBL31496832 | 0.72 | CYP3A4 (0.53) | KDM4EGAASMN1; SMN2MAOAMAOB | |
| SCHEMBL29914938 | 0.72 | KDM4E (0.41) | KDM4EGAASMN1; SMN2MAOAMAOB | |
| SCHEMBL27002518 | 0.72 | KDM4E (0.41) | KDM4EGAASMN1; SMN2MAOAMAOB | |
| SCHEMBL31496867 | 0.69 | MAOA (0.36) | KDM4EGAASMN1; SMN2MAOAMAOB | |
| SCHEMBL286550 | 0.69 | KDM4E (0.39) | KDM4EGAASMN1; SMN2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115427109-A | Heterocyclic compounds as dihydroorotate dehydrogenase inhibitors | 詹森生物科技公司 | 2022-12-02 | — | — | CN | disclosed |