SCHEMBL2890089

SCHEMBL2890089

O=C1c2ccccc2C(=O)N1c1cccc(Cl)c1N1C(=O)c2ccccc2C1=O

nearest known ligand 0.60

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.60
MEN1 O00255 3/20 0.60
POLB P06746 1/20 0.53
CYP3A4 P08684 1/20 0.51
NFKB1 P19838 1/20 0.51
PMP22 Q01453 1/20 0.51
PGR P06401 1/20 0.46
MAPK14 Q16539 1/20 0.44
MGLL Q99685 1/20 0.44
NR1H2 P55055 2/20 0.44
NR1H3 Q13133 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2549717 0.84 MEN1 (0.73) KMT2AMEN1POLBCYP3A4NFKB1
SCHEMBL30758582 0.83 KMT2A (0.62) KMT2AMEN1POLBCYP3A4NFKB1
SCHEMBL29168847 0.83 KMT2A (0.62) KMT2AMEN1POLBCYP3A4NFKB1
SCHEMBL30758612 0.80 KMT2A (0.58) KMT2AMEN1POLBCYP3A4NFKB1
SCHEMBL10824922 0.80 KMT2A (0.58) KMT2AMEN1POLBCYP3A4NFKB1
SCHEMBL13665449 0.80 KMT2A (0.58) KMT2AMEN1POLBCYP3A4NFKB1
SCHEMBL3979412 0.78 KMT2A (0.60) KMT2AMEN1POLBCYP3A4NFKB1
SCHEMBL10640082 0.77 KMT2A (0.55) KMT2AMEN1POLBCYP3A4NFKB1
SCHEMBL4649466 0.77 POLB (0.65) KMT2AMEN1POLBCYP3A4NFKB1
SCHEMBL30596240 0.76 CES1 (0.58) KMT2AMEN1CYP3A4MAPK14MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2009521548-A 2009-06-04 JP claimed
EP-1966320-A2 HIGH GLASS TRANSITION TEMPERATURE THERMOPLASTIC ARTICLES General Electric Company (US) 2008-09-10 EP claimed
EP-1963432-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS General Electric Company (US) 2008-09-03 EP claimed
WO-2007078737-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS GENERAL ELECTRIC COMPANY (US) 2007-07-12 WO claimed
WO-2007078713-A2 HIGH GLASS TRANSITION TEMPERATURE THERMOPLASTIC ARTICLES GENERAL ELECTRIC COMPANY (US) 2007-07-12 WO claimed
US-20070149629-A1 Expanded and expandable high glass transition temperature polymers CITIBANK, N.A., AS COLLATERAL AGENT 2007-06-28 US claimed
US-20070066739-A1 Coated articles of manufacture made of high Tg polymer blends GENERAL ELECTRIC COMPANY 2007-03-22 US claimed
US-20070066741-A1 High glass transition temperature thermoplastic articles CITIBANK, N.A., AS COLLATERAL AGENT 2007-03-22 US claimed
EP-1660556-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2006-05-31 EP claimed
WO-2005023901-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2005-03-17 WO claimed
US-6849706-B1 Copolyetherimides GENERAL ELECTRIC COMPANY (US) 2005-02-01 US claimed
EP-1660560-B1 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETEHRIMIDES SABIC GLOBAL TECHNOLOGIES BV (NL) 2016-03-23 EP disclosed
US-7714095-B2 Phase transfer catalyzed method for preparation of polyetherimides SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-05-11 US disclosed
EP-1660556-B1 COPOLYETHERIMIDES SABIC INNOVATIVE PLASTICS IP (NL) 2009-05-13 EP disclosed
EP-1989246-A2 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETHERIMIDES Sabic Innovative Plastics IP B.V. (NL) 2008-11-12 EP disclosed
EP-1660556-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2006-05-31 EP disclosed
WO-2005023901-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2005-03-17 WO disclosed
WO-2005021618-A2 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETEHRIMIDES GENERAL ELECTRIC COMPANY (US) 2005-03-10 WO disclosed
US-20050049390-A1 Phase transfer catalyzed method for preparation of polyetherimides GENERAL ELECTRIC COMPANY 2005-03-03 US disclosed
US-6849706-B1 Copolyetherimides GENERAL ELECTRIC COMPANY (US) 2005-02-01 US disclosed