SCHEMBL3979412

SCHEMBL3979412

O=C1c2cccc(Cl)c2C(=O)N1c1ccccc1N1C(=O)c2cccc(Cl)c2C1=O

nearest known ligand 0.60

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.60
MEN1 O00255 2/20 0.60
NR1H2 P55055 1/20 0.51
GRM4 Q14833 4/20 0.51
PGR P06401 1/20 0.50
POLB P06746 1/20 0.49
CYP3A4 P08684 1/20 0.47
NFKB1 P19838 1/20 0.47
PMP22 Q01453 1/20 0.47
GRM1 Q13255 5/20 0.47
LMNA P02545 1/20 0.47
HSPA1A P0DMV8 1/20 0.46
PABPC1 P11940 1/20 0.46
MGLL Q99685 1/20 0.44
NSD2 O96028 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19365875 0.89 NR1H2 (0.69) KMT2AMEN1NR1H2GRM4PGR
SCHEMBL3819605 0.88 MEN1 (0.51) KMT2AMEN1NR1H2GRM4PGR
SCHEMBL1500541 0.84 HSPA1A (0.67) KMT2AMEN1GRM4PGRPOLB
SCHEMBL1735119 0.83 MEN1 (0.58) KMT2AMEN1GRM4GRM1HSPA1A
SCHEMBL2892154 0.82 KMT2A (0.47) KMT2AMEN1NR1H2GRM4PGR
SCHEMBL2890258 0.81 HSPA1A (0.54) KMT2AMEN1PGRHSPA1APABPC1
SCHEMBL2549717 0.80 MEN1 (0.73) KMT2AMEN1NR1H2PGRPOLB
SCHEMBL7768240 0.80 KMT2A (0.45) KMT2AMEN1NR1H2GRM4PGR
SCHEMBL1736347 0.80 HSPA1A (0.53) KMT2AMEN1GRM4PGRGRM1
SCHEMBL29168847 0.79 KMT2A (0.62) KMT2AMEN1NR1H2PGRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1660556-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2006-05-31 EP claimed
WO-2005023901-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2005-03-17 WO claimed
US-6849706-B1 Copolyetherimides GENERAL ELECTRIC COMPANY (US) 2005-02-01 US claimed
EP-2064263-A1 METHOD FOR PRODUCING POLYETHER POLYMERS Sabic Innovative Plastics IP B.V. (NL) 2009-06-03 EP disclosed
EP-1660556-B1 COPOLYETHERIMIDES SABIC INNOVATIVE PLASTICS IP (NL) 2009-05-13 EP disclosed
WO-2008030229-A1 METHOD FOR PRODUCING POLYETHER POLYMERS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-03-13 WO disclosed
US-7125954-B2 Method for producing polyether polymers GENERAL ELECTRIC COMPANY (US) 2006-10-24 US disclosed
US-20060167210-A1 Method for producing polyether polymers SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2006-07-27 US disclosed
EP-1660556-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2006-05-31 EP disclosed
EP-1660543-A1 PROCESS FOR FRACTIONATION/CONCENTRATION TO REDUCE THE POLYDISPERSIVITY OF POLYMERS GENERAL ELECTRIC COMPANY (US) 2006-05-31 EP disclosed
US-6906168-B2 Process for fractionation/concentration to reduce the polydispersivity of polymers GENERAL ELECTRIC COMPANY (US) 2005-06-14 US disclosed
WO-2005023901-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2005-03-17 WO disclosed
WO-2005021599-A1 PROCESS FOR FRACTIONATION/CONCENTRATION TO REDUCE THE POLYDISPERSIVITY OF POLYMERS GENERAL ELECTRIC COMPANY (US) 2005-03-10 WO disclosed
US-20050049392-A1 Process for fractionation/concentration to reduce the polydispersivity of polymers SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2005-03-03 US disclosed
US-6849706-B1 Copolyetherimides GENERAL ELECTRIC COMPANY (US) 2005-02-01 US disclosed
US-6265521-B1 USING ALKALI METAL SALT OF A DIHYDROXY-SUBSTITUTED AROMATIC HYDROCARBON GENERAL ELECTRIC COMPANY 2001-07-24 US disclosed