Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 2/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | FLT1 | P17948 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30447715 | 0.93 | KDR (0.71) | KDRPDGFRAMETRAF1PDGFRB | |
| SCHEMBL30448158 | 0.93 | MET (0.65) | KDRPDGFRAMETRAF1CSF1R | |
| SCHEMBL28900931 | 0.89 | KDR (0.57) | KDRPDGFRAMETRAF1PDGFRB | |
| SCHEMBL30448135 | 0.89 | KDR (0.57) | KDRPDGFRAMETRAF1PDGFRB | |
| SCHEMBL28473758 | 0.88 | KDR (0.59) | KDRPDGFRAMETRAF1PDGFRB | |
| SCHEMBL30447680 | 0.88 | KDR (0.58) | KDRPDGFRAMETRAF1PDGFRB | |
| SCHEMBL28476822 | 0.87 | KDR (0.74) | KDRPDGFRARAF1PDGFRBFLT1 | |
| SCHEMBL30448047 | 0.87 | KDR (0.74) | KDRPDGFRARAF1PDGFRBFLT1 | |
| SCHEMBL28471921 | 0.87 | KDR (0.57) | KDRPDGFRAMETRAF1PDGFRB | |
| SCHEMBL30447991 | 0.86 | KDR (0.61) | KDRPDGFRAMETRAF1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825605-B | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-03-31 | — | — | CN | disclosed |
| CN-111825605-A | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2020-10-27 | — | — | CN | disclosed |