Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 2/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 3/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30447813 | 0.91 | KDR (0.56) | KDRPDGFRACSF1RMETABCG2 | |
| SCHEMBL30447715 | 0.90 | KDR (0.71) | KDRPDGFRACSF1RMETPDGFRB | |
| SCHEMBL30448158 | 0.89 | MET (0.65) | KDRPDGFRACSF1RMETBRAF | |
| SCHEMBL28900930 | 0.88 | KDR (0.69) | KDRPDGFRACSF1RMETPDGFRB | |
| SCHEMBL28979425 | 0.86 | BRAF (0.56) | KDRPDGFRABRAFRAF1MAPK14 | |
| SCHEMBL30447912 | 0.86 | BRAF (0.56) | KDRPDGFRABRAFRAF1MAPK14 | |
| SCHEMBL28473758 | 0.85 | KDR (0.59) | KDRPDGFRACSF1RMETPDGFRB | |
| SCHEMBL28476822 | 0.84 | KDR (0.74) | KDRPDGFRACSF1RPDGFRBBRAF | |
| SCHEMBL30448047 | 0.84 | KDR (0.74) | KDRPDGFRACSF1RPDGFRBBRAF | |
| SCHEMBL28471921 | 0.84 | KDR (0.57) | KDRPDGFRACSF1RMETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825605-B | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-03-31 | — | — | CN | disclosed |