Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | KLK7 | P49862 | 2/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PRCP | P42785 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30845587 | 0.85 | PREP (0.53) | PREPTSHRKLK7KLK5CYP3A4 | |
| SCHEMBL16105052 | 0.81 | FKBP1A (0.50) | PREPTSHRCYP3A4MAPTCYP2C9 | |
| SCHEMBL10310512 | 0.81 | PREP (0.56) | PREPTSHRRAB9ANPSR1ACE2 | |
| SCHEMBL3011829 | 0.81 | PREP (0.56) | PREPTSHRRAB9ANPSR1ACE2 | |
| SCHEMBL14635896 | 0.80 | PREP (0.55) | PREPTSHRRAB9ANPSR1ACE2 | |
| SCHEMBL3088051 | 0.80 | PREP (0.55) | PREPTSHRRAB9ANPSR1ACE2 | |
| SCHEMBL3076586 | 0.80 | PREP (0.55) | PREPTSHRRAB9ANPSR1ACE2 | |
| SCHEMBL3088055 | 0.80 | PREP (0.55) | PREPTSHRRAB9ANPSR1ACE2 | |
| SCHEMBL12612788 | 0.80 | PREP (0.55) | PREPTSHRRAB9ANPSR1ACE2 | |
| SCHEMBL14635897 | 0.80 | PREP (0.55) | PREPTSHRRAB9ANPSR1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118005640-A | GCN2 inhibitors and uses thereof | 默克专利股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-111918651-B | GCN2 inhibitors and uses thereof | 默克专利股份有限公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-111918651-A | GCN2 inhibitors and uses thereof | 默克专利股份有限公司 | 2020-11-10 | — | — | CN | disclosed |