SCHEMBL28901210

SCHEMBL28901210

NC(=O)OCC(=CF)COc1ccc(C(=O)N2Cc3ccc(Cl)cc3C2)cc1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AOC2 O75106 2/20 0.42
CPT2 P23786 1/20 0.40
CPT1A P50416 1/20 0.40
AOC3 Q16853 8/20 0.39
MAOB P27338 2/20 0.39
ALDH1A1 P00352 2/20 0.39
TSHR P16473 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
MAPT P10636 2/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
POLB P06746 1/20 0.36
ENPP2 Q13822 1/20 0.36
ATXN2 Q99700 1/20 0.36
KCNA5 P22460 2/20 0.36
DRD3 P35462 1/20 0.36
DRD2 P14416 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21780048 0.90 AOC2 (0.52) AOC2AOC3MAOB
Trifluoroacetic Acid SCHEMBL21768119 0.85 AOC2 (0.48) AOC2AOC3MAOB
SCHEMBL21768104 0.84 CPT2 (0.41) AOC2CPT2CPT1AAOC3MAOB
SCHEMBL21768105 0.84 CPT2 (0.41) AOC2CPT2CPT1AAOC3MAOB
SCHEMBL21780106 0.78 CPT2 (0.43) CPT2CPT1AAOC3MAOBALDH1A1
SCHEMBL21780132 0.70 AOC2 (0.56) AOC2AOC3MAOBMAPT
SCHEMBL21780142 0.70 AOC2 (0.56) AOC2AOC3MAOBMAPT
SCHEMBL21768167 0.70 MAOB (0.56) MAOBALDH1A1POLBENPP2ATXN2
SCHEMBL30089453 0.70 MAOB (0.56) MAOBALDH1A1POLBENPP2ATXN2
SCHEMBL21780087 0.69 AOC3 (0.52) AOC2AOC3MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110352188-B Fluoroallylamine derivatives and use thereof 四川科伦博泰生物医药股份有限公司 2022-11-29 CN disclosed