Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27691058 | 1.00 | CA1 (0.62) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL28577539 | 0.94 | CA1 (0.71) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL29181726 | 0.94 | CA1 (0.71) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL27082179 | 0.94 | CA1 (0.71) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL47980 | 0.94 | CA1 (0.71) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL11280337 | 0.94 | — | — | |
| Bicarbonate SCHEMBL28358443 | 0.88 | CA1 (0.62) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL5082549 | 0.88 | CA1 (0.62) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL12489460 | 0.88 | CA1 (0.62) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL641446 | 0.88 | CA1 (0.62) | CA1CA2CA9FFAR3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10111446-B2 | Fatty acid vinyl ester copolymers with wax qualities | WACKER CHEMIE AG (DE) | 2018-10-30 | — | — | US | disclosed |
| US-20170208828-A1 | FATTY ACID VINYL ESTER COPOLYMERS WITH WAX QUALITIES | WACKER CHEMIE AG (DE) | 2017-07-27 | — | — | US | disclosed |
| US-8268923-B2 | Production of solutions of vinyl polymers in reactive monomers | WACKER CHEMIE AG (DE) | 2012-09-18 | — | — | US | disclosed |
| US-20100286347-A1 | PRODUCTION OF SOLUTIONS OF VINYL POLYMERS IN REACTIVE MONOMERS | WACKER CHEMIE AG (DE) | 2010-11-11 | — | — | US | disclosed |
| US-20100227995-A1 | PRODUCTION OF VINYL ACETATE - VINYL ESTER COPOLYMERS HAVING A LOW CONTENT OF HIGH-BOILING VINYL ESTERS | WACKER CHEMIE AG (DE) | 2010-09-09 | — | — | US | disclosed |
| US-20090182090-A1 | USE OF CARBOXYL-FUNCTIONAL POLYVINYL ACETATES FOR PRODUCING BMC PARTS | WACKER CHEMIE AG (DE) | 2009-07-16 | — | — | US | disclosed |
| US-20090105406-A1 | USE OF FUNCTIONALIZED POLYVINYL ESTERS FOR INCREASING THE SURFACE TENSION OF BMC/SMC PARTS | WACKER CHEMIE AG (DE) | 2009-04-23 | — | — | US | disclosed |
| US-20080015321-A1 | Non-Blocking Solid Resins Of Vinyl Ester Mixed Polymers | WACKER POLYMER SYSTEMS GMBH & CO. KG (DE) | 2008-01-17 | — | — | US | disclosed |
| US-20070265394-A1 | Polyvinyl Acetate Solid Resins Functionalised with Acid Groups | WACKER POLYMER SYSTEMS GMBH & CO. KG (DE) | 2007-11-15 | — | — | US | disclosed |