Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL12489460 | 1.00 | CA1 (0.62) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL11280337 | 0.94 | — | — | |
| Bicarbonate SCHEMBL27082179 | 0.94 | CA1 (0.71) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL28577539 | 0.94 | CA1 (0.71) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL29181726 | 0.94 | CA1 (0.71) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL47980 | 0.94 | CA1 (0.71) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL2890152 | 0.88 | CA1 (0.62) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL28358443 | 0.88 | CA1 (0.62) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL5082549 | 0.88 | CA1 (0.62) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL28623473 | 0.88 | CA1 (0.62) | CA1CA2CA9FFAR3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11817545-B2 | Secondary electrochemical cells with separator and electrolyte combination | DURACELL U.S. OPERATIONS, INC. (US) | 2023-11-14 | — | — | US | claimed |
| EP-3645655-B1 | POLYMER LIQUID COMPOSITES FOR IMPROVED ANTI-FOULING PERFORMANCE | HRL LAB LLC (US) | 2023-09-27 | — | — | EP | claimed |
| CN-111655791-B | Pest and ice phobic compositions with fluid additives | HRL实验室有限责任公司 | 2022-11-04 | — | — | CN | claimed |
| CN-110799619-B | Polymer-liquid composites for improved antifouling properties | HRL实验室有限责任公司 | 2022-04-26 | — | — | CN | claimed |
| US-20210367262-A1 | SECONDARY ELECTROCHEMICAL CELLS WITH SEPARATOR AND ELECTROLYTE COMBINATION | DURACELL U.S. OPERATIONS, INC. (US) | 2021-11-25 | — | — | US | claimed |
| EP-3526295-B1 | BUGPHOBIC AND ICEPHOBIC COMPOSITIONS WITH LIQUID ADDITIVES | HRL LAB LLC (US) | 2021-08-04 | — | — | EP | claimed |
| US-11081721-B2 | Secondary electrochemical cells with separator and electrolyte combination | DURACELL U.S. OPERATIONS, INC. (US) | 2021-08-03 | — | — | US | claimed |
| US-11072713-B2 | Bugphobic and icephobic compositions with fluid additives | HRL LABORATORIES, LLC (US) | 2021-07-27 | — | — | US | claimed |
| US-11034846-B2 | Polymer-liquid composites for improved anti-fouling performance | HRL LABORATORIES, LLC (US) | 2021-06-15 | — | — | US | claimed |
| CN-109804029-B | Pest and ice phobic compositions with liquid additives | HRL实验室有限责任公司 | 2021-05-25 | — | — | CN | claimed |
| EP-3526295-A1 | BUGPHOBIC AND ICEPHOBIC COMPOSITIONS WITH LIQUID ADDITIVES | HRL Laboratories, LLC (US) | 2019-08-21 | — | — | EP | claimed |
| WO-2019152081-A1 | BUGPHOBIC AND ICEPHOBIC COMPOSITIONS WITH FLUID ADDITIVES | HRL LABORATORIES, LLC (US) | 2019-08-08 | — | — | WO | claimed |
| US-20190023910-A1 | BUGPHOBIC AND ICEPHOBIC COMPOSITIONS WITH FLUID ADDITIVES | HRL LABORATORIES, LLC | 2019-01-24 | — | — | US | claimed |
| WO-2019005272-A1 | POLYMER–LIQUID COMPOSITES FOR IMPROVED ANTI-FOULING PERFORMANCE | HRL LABORATORIES, LLC (US) | 2019-01-03 | — | — | WO | claimed |
| US-20180237643-A1 | POLYMER-LIQUID COMPOSITES FOR IMPROVED ANTI-FOULING PERFORMANCE | HRL LABORATORIES, LLC | 2018-08-23 | — | — | US | claimed |
| WO-2018071349-A1 | BUGPHOBIC AND ICEPHOBIC COMPOSITIONS WITH LIQUID ADDITIVES | HRL LABORATORIES, LLC (US) | 2018-04-19 | — | — | WO | claimed |
| US-20180030329-A1 | BUGPHOBIC AND ICEPHOBIC COMPOSITIONS WITH LIQUID ADDITIVES | HRL LABORATORIES, LLC | 2018-02-01 | — | — | US | claimed |
| US-20160351942-A9 | SECONDARY ELECTROCHEMICAL CELLS WITH SEPARATOR AND ELECTROLYTE COMBINATION | DURACELL U.S. OPERATIONS, INC. (US) | 2016-12-01 | — | — | US | claimed |
| WO-2013180923-A1 | SECONDARY ELECTROCHEMICAL CELLS WITH SEPARATOR AND ELECTROLYTE COMBINATION | THE GILLETTE COMPANY (US) | 2013-12-05 | — | — | WO | claimed |
| US-20130323607-A1 | SECONDARY ELECTROCHEMICAL CELLS WITH SEPARATOR AND ELECTROLYTE COMBINATION | ISSAEV NIKOLAI NIKOLAEVICH (US) | 2013-12-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11072713-B2 | Bugphobic and icephobic compositions with fluid additives | FUS, IGF2BP1, IGF2BP3 | CA1 1418/4885CA2 1690/4885CA9 3032/4885 |
| US-20180030329-A1 | BUGPHOBIC AND ICEPHOBIC COMPOSITIONS WITH LIQUID ADDITIVES | SLC14A1, MYB, FUS | CA1 1052/4885CA2 1264/4885CA9 2560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.