Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK3 | P52333 | 4/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28903935 | 0.87 | SMPD3 (0.39) | AAK1DYRK1ASMPD3CSNK2A1CSNK2A2 | |
| SCHEMBL31677677 | 0.85 | AAK1 (0.48) | AAK1FYNFFAR4SMPD3JAK2 | |
| SCHEMBL20081018 | 0.84 | AAK1 (0.50) | AAK1FYNSMPD3JAK2JAK3 | |
| SCHEMBL29660254 | 0.79 | AAK1 (0.56) | AAK1FYNFFAR4SMPD3JAK2 | |
| SCHEMBL29660313 | 0.77 | AAK1 (0.58) | AAK1FYNFFAR4SMPD3JAK2 | |
| SCHEMBL19466908 | 0.75 | AAK1 (0.49) | AAK1DYRK1AFFAR4CSNK2A1CSNK2A2 | |
| SCHEMBL29660359 | 0.75 | AAK1 (0.47) | AAK1FYNFFAR4JAK2JAK3 | |
| SCHEMBL31441708 | 0.72 | RET (0.47) | AAK1FYNJAK2JAK3PTK2 | |
| SCHEMBL16553421 | 0.72 | AAK1 (0.49) | AAK1FYNFFAR4JAK2JAK3 | |
| SCHEMBL23931668 | 0.72 | AAK1 (0.72) | AAK1JAK2JAK3PTK2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115427045-A | 4- (3- (pyridin-3-yl) pyrazolo [1,5-a ] pyrimidin-5-yl) piperazine for the treatment of COV-229E or COV-OC43 coronavirus infection | 莱西肯医药有限公司 | 2022-12-02 | — | — | CN | disclosed |