Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.50 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 5/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31677677 | 0.88 | AAK1 (0.48) | AAK1SMPD3FYNPSEN1PSEN2 | |
| SCHEMBL28903853 | 0.84 | AAK1 (0.45) | AAK1SMPD3FYNPSEN1PSEN2 | |
| SCHEMBL29660313 | 0.80 | AAK1 (0.58) | AAK1SMPD3FYNPSEN1PSEN2 | |
| SCHEMBL29660254 | 0.79 | AAK1 (0.56) | AAK1SMPD3FYNPSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL30172429 | 0.76 | BMP4 (0.50) | AAK1SMPD3PSEN1PSEN2APH1B | |
| SCHEMBL19466908 | 0.75 | AAK1 (0.49) | AAK1TGFBR1 | |
| SCHEMBL31441471 | 0.75 | FYN (0.52) | AAK1FYNTGFBR1ACVR2ATGFBR2 | |
| SCHEMBL23931665 | 0.75 | AAK1 (0.54) | AAK1FYNPSEN1PSEN2APH1B | |
| SCHEMBL30103024 | 0.75 | AAK1 (0.52) | AAK1FYNPSEN1PSEN2APH1B | |
| SCHEMBL30102937 | 0.75 | AAK1 (0.54) | AAK1FYNPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834243-B1 | PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2018-04-25 | — | — | EP | disclosed |