Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 15/20 | 0.85 |
| ▸ | RARG | P13631 | 15/20 | 0.85 |
| ▸ | RXRA | P19793 | 14/20 | 0.85 |
| ▸ | RARA | P10276 | 12/20 | 0.85 |
| ▸ | RXRB | P28702 | 3/20 | 0.85 |
| ▸ | RXRG | P48443 | 3/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.63 |
| ▸ | GMNN | O75496 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2890391 | 1.00 | RARB (0.85) | RARBRARGRXRARARARXRB | |
| SCHEMBL10843201 | 0.93 | RXRA (0.81) | RARBRARGRXRARARARXRB | |
| SCHEMBL10841254 | 0.93 | RXRA (0.81) | RARBRARGRXRARARARXRB | |
| SCHEMBL10846860 | 0.93 | RARB (0.73) | RARBRARGRXRARARARXRB | |
| SCHEMBL10846856 | 0.93 | RARB (0.73) | RARBRARGRXRARARARXRB | |
| SCHEMBL10844085 | 0.92 | RXRA (0.80) | RARBRARGRXRARARARXRB | |
| SCHEMBL10844087 | 0.92 | RXRA (0.80) | RARBRARGRXRARARARXRB | |
| SCHEMBL9007272 | 0.92 | RARB (1.00) | RARBRARGRXRARARARXRB | |
| SCHEMBL9007266 | 0.92 | RARB (1.00) | RARBRARGRXRARARARXRB | |
| SCHEMBL9007264 | 0.92 | RARB (1.00) | RARBRARGRXRARARARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968602-B2 | 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1-propenyl]benzoic acid analogs and method of manufacture and use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-06-28 | — | — | US | disclosed |
| US-20100029777-A1 | 4-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-04 | — | — | US | disclosed |
| US-7585894-B2 | 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1-propenyl]benzoic acid analogs and method of manufacture and use thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-09-08 | — | — | US | disclosed |
| US-20070015717-A1 | 4-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND USE THEREOF | UNIVERSITY OF CALIFORNIA-LOS ANGELES | 2007-01-18 | — | — | US | disclosed |
| US-4578498-A | FOR SKIN DISORDERS; REDUCED TOXICITY | BASF AKTIENGESELLSCHAFT (DE) | 1986-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029777-A1 | 4-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND USE THEREOF | BRCA1, TTPA, UGT2B7 | RARB 393/4885RARG 390/4885RXRA 566/4885 |
| US-20070015717-A1 | 4-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND USE THEREOF | BRCA1, TTPA, UGT2B7 | RARB 393/4885RARG 390/4885RXRA 566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.