Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.61 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15961317 | 0.87 | PRSS1 (0.58) | PRSS1PRSS2PRSS3ALDH1A1CES2 | |
| SCHEMBL211017 | 0.81 | ALDH1A1 (0.67) | PRSS1PRSS2PRSS3ALDH1A1CES2 | |
| SCHEMBL2892439 | 0.81 | ALDH1A1 (0.71) | PRSS1PRSS2PRSS3ALDH1A1CES2 | |
| SCHEMBL258588 | 0.81 | PRSS1 (0.58) | PRSS1PRSS2PRSS3ALDH1A1CES2 | |
| SCHEMBL14290247 | 0.80 | ALDH1A1 (0.60) | PRSS1PRSS2PRSS3ALDH1A1CES2 | |
| Hydrochloric Acid SCHEMBL258587 | 0.80 | PRSS1 (0.60) | PRSS1PRSS2PRSS3ALDH1A1CES2 | |
| SCHEMBL2762350 | 0.77 | PRSS1 (0.96) | PRSS1PRSS2PRSS3ALDH1A1CES2 | |
| SCHEMBL7645485 | 0.77 | ALDH1A1 (0.76) | PRSS1PRSS2PRSS3ALDH1A1CES2 | |
| Alcohol SCHEMBL11784636 | 0.77 | ALDH1A1 (0.87) | PRSS1PRSS2PRSS3ALDH1A1CES2 | |
| Butane SCHEMBL27774502 | 0.77 | TP53 (0.83) | PRSS1PRSS2PRSS3ALDH1A1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461160-B2 | Dihydropyrimidinones | HOFFMANN-LA ROCHE, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20100286158-A1 | DIHYDROPYRIMIDINONES | HOFFMANN-LA ROCHE, INC. | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286158-A1 | DIHYDROPYRIMIDINONES | BACE2, BACE1, PSEN2 | PRSS1 30/4885PRSS2 27/4885PRSS3 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.