Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28509618 | 0.97 | JAK2 (0.56) | JAK2MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL28509463 | 0.79 | MAP3K11 (0.48) | MAPT | |
| SCHEMBL28905289 | 0.78 | MAP4K1 (0.58) | — | |
| SCHEMBL28513553 | 0.76 | MAP3K11 (0.49) | MAPT | |
| SCHEMBL28506202 | 0.73 | JAK2 (0.62) | JAK2 | |
| SCHEMBL8483472 | 0.73 | RAB9A (0.74) | MAPTRAB9ASMN1; SMN2TDP1HPGD | |
| SCHEMBL10682756 | 0.72 | RAB9A (0.72) | MAPTRAB9ASMN1; SMN2TDP1HPGD | |
| SCHEMBL10675533 | 0.72 | RAB9A (0.72) | MAPTRAB9ASMN1; SMN2TDP1HPGD | |
| SCHEMBL10683824 | 0.72 | RAB9A (0.72) | MAPTRAB9ASMN1; SMN2TDP1HPGD | |
| SCHEMBL10675006 | 0.72 | RAB9A (0.72) | MAPTRAB9ASMN1; SMN2TDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |