Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.48 |
| ▸ | IL2 | P60568 | 3/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28513553 | 0.98 | MAP3K11 (0.49) | MAP3K11TNIKMAP4K1IL2PIK3CG | |
| SCHEMBL28905289 | 0.87 | MAP4K1 (0.58) | MAP3K11TNIKMAP4K1IL2 | |
| SCHEMBL21592846 | 0.86 | MAP3K11 (0.53) | MAP3K11TNIKMAP4K1IL2 | |
| SCHEMBL21592832 | 0.85 | MAP3K11 (0.54) | MAP3K11TNIKMAP4K1IL2 | |
| SCHEMBL28906168 | 0.81 | MAP4K1 (0.56) | MAP3K11TNIKMAP4K1IL2PIK3CG | |
| SCHEMBL21592695 | 0.81 | MAP4K1 (0.56) | MAP3K11TNIKMAP4K1IL2 | |
| SCHEMBL21592809 | 0.79 | MAP4K1 (0.57) | MAP3K11TNIKMAP4K1IL2 | |
| SCHEMBL28905296 | 0.79 | JAK2 (0.55) | MAPT | |
| SCHEMBL28507129 | 0.78 | TNIK (0.59) | MAP3K11TNIKMAP4K1IL2 | |
| SCHEMBL28513938 | 0.78 | MAP4K1 (0.56) | MAP3K11TNIKMAP4K1IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |