Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28513992 | 0.92 | DPP4 (0.38) | DPP4ACHEBCHECCNE1CDK2 | |
| SCHEMBL28511456 | 0.84 | DPP9 (0.34) | ACHEBCHECYP2D6SLC6A2SLC6A4 | |
| SCHEMBL29891133 | 0.77 | RORC (0.37) | DPP4HTR2AHTR2CKDM1ADPP8 | |
| SCHEMBL23046128 | 0.77 | RORC (0.37) | DPP4HTR2AHTR2CKDM1ADPP8 | |
| SCHEMBL21397469 | 0.75 | DPP4 (0.37) | DPP4HTR2AHTR2CSLC9A3SLC6A2 | |
| SCHEMBL21383892 | 0.71 | DPP4 (0.40) | DPP4HTR2AHTR2CKDM1ACYP2D6 | |
| SCHEMBL29891089 | 0.70 | NPY5R (0.36) | DPP4KDM1ACYP2D6DPP8DPP9 | |
| SCHEMBL23046130 | 0.70 | NPY5R (0.36) | DPP4KDM1ACYP2D6DPP8DPP9 | |
| SCHEMBL21383810 | 0.69 | HTR2C (0.41) | DPP4HTR2AHTR2CKDM1ASLC6A2 | |
| SCHEMBL29726234 | 0.69 | HTR2C (0.41) | DPP4HTR2AHTR2CKDM1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117263942-A | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-112166110-B | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-112166110-A | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2021-01-01 | — | — | CN | disclosed |