Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 17/20 | 1.00 |
| ▸ | ACHE | P22303 | 14/20 | 0.84 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28906880 | 0.91 | GSK3B (1.00) | GSK3BACHEBCHE | |
| SCHEMBL28517234 | 0.91 | GSK3B (1.00) | GSK3BACHEACKR3BCHE | |
| SCHEMBL28906889 | 0.87 | GSK3B (1.00) | GSK3BACHEBCHEMAPT | |
| SCHEMBL28512652 | 0.87 | GSK3B (1.00) | GSK3BACHEBCHEMAPT | |
| SCHEMBL28905775 | 0.87 | GSK3B (1.00) | GSK3BACHEBCHEMAPT | |
| SCHEMBL28505211 | 0.84 | GSK3B (1.00) | GSK3BACHEBCHEMAPT | |
| SCHEMBL28510938 | 0.80 | GSK3B (0.69) | GSK3BACHEBCHEMAPT | |
| SCHEMBL29960710 | 0.80 | GSK3B (0.69) | GSK3BACHEBCHEMAPT | |
| SCHEMBL29960939 | 0.78 | CACNA1I (0.66) | GSK3BACKR3 | |
| SCHEMBL28517208 | 0.78 | GSK3B (1.00) | GSK3BACHEBCHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112047928-B | Isonicotinamide AChE-GSK3 double inhibitor and preparation method and application thereof | 中国药科大学 | 2022-09-23 | — | — | CN | claimed |
| CN-112047928-A | Isonicotinamide AChE-GSK3 double inhibitor and preparation method and application thereof | 中国药科大学 | 2020-12-08 | — | — | CN | claimed |
| CN-112047928-B | Isonicotinamide AChE-GSK3 double inhibitor and preparation method and application thereof | 中国药科大学 | 2022-09-23 | — | — | CN | disclosed |
| CN-112047928-A | Isonicotinamide AChE-GSK3 double inhibitor and preparation method and application thereof | 中国药科大学 | 2020-12-08 | — | — | CN | disclosed |