SCHEMBL28906121

SCHEMBL28906121

Cn1nnc(-c2ccc(Cl)cc2)c1Cn1ncc(N2CC(OC(F)C(F)F)C2)cc1=O

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCNC P24863 1/20 0.31
CDK8 P49336 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26096872 0.91 CCNC (0.31) CCNCCDK8
SCHEMBL28906125 0.89 MCHR1 (0.32)
SCHEMBL26095518 0.87 AXL (0.34) CCNCCDK8
SCHEMBL24034728 0.86 CCNC (0.31) CCNCCDK8
SCHEMBL24034886 0.83 KMT2A (0.38) CCNCCDK8
SCHEMBL24034902 0.83 MCHR1 (0.33)
SCHEMBL28906114 0.82
SCHEMBL24034842 0.81 MCHR1 (0.33)
SCHEMBL28906127 0.81 MCHR1 (0.34)
SCHEMBL24034705 0.80 MCHR1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115461337-A Novel triazolyl derivatives as GABA A alpha 5 PAM 豪夫迈·罗氏有限公司 2022-12-09 CN claimed
CN-115461337-A Novel triazolyl derivatives as GABA A alpha 5 PAM 豪夫迈·罗氏有限公司 2022-12-09 CN disclosed