Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | C1S | P09871 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30540400 | 0.94 | ALDH1A1 (0.39) | KDM1AALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL3963493 | 0.91 | ALDH1A1 (0.46) | KDM1AALDH1A1MAPK1HTR2AHTR2C | |
| SCHEMBL30540397 | 0.73 | ALDH1A1 (0.48) | KDM1AALDH1A1MAPK1HTR2AMEN1 | |
| SCHEMBL4949117 | 0.73 | ACHE (0.48) | ALDH1A1MAPK1HTR2AHTR2CHTR2B | |
| SCHEMBL2898174 | 0.73 | ALDH1A1 (0.39) | ALDH1A1HTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL29085620 | 0.71 | MAOB (0.47) | ALDH1A1MAPK1TAAR1 | |
| SCHEMBL28873734 | 0.70 | MAOB (0.46) | ALDH1A1MAPK1TAAR1 | |
| SCHEMBL10958964 | 0.69 | ALDH1A1 (0.39) | KDM1AALDH1A1MAPK1HTR2CHTR2B | |
| SCHEMBL7680400 | 0.69 | ALDH1A1 (0.39) | KDM1AALDH1A1MAPK1HTR2CHTR2B | |
| SCHEMBL5556827 | 0.69 | ALDH1A1 (0.39) | KDM1AALDH1A1MAPK1HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678796-B2 | MGluR5 modulators I | ASTRAZENECA AB (SE) | 2010-03-16 | — | — | US | disclosed |
| US-20070259926-A1 | mGluR5 modulators III | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| US-20070259916-A1 | mGluR5 modulators II | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| US-20070259862-A1 | MGluR5 modulators I | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259862-A1 | MGluR5 modulators I | GRM5, GRM1, GRIK5 | KDM1A 3180/4885ALDH1A1 4350/4885MAPK1 1996/4885 |
| US-20070259926-A1 | mGluR5 modulators III | GRM5, GRM3, GRIK5 | KDM1A 3533/4885ALDH1A1 4536/4885MAPK1 2236/4885 |
| US-20070259916-A1 | mGluR5 modulators II | GRM5, GRM2, GRIK5 | KDM1A 3618/4885ALDH1A1 4552/4885MAPK1 2361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.