Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | CLPP | Q16740 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1326372 | 0.82 | MEN1 (0.36) | SIGMAR1DRD4MEN1KMT2ANPC1 | |
| SCHEMBL2111899 | 0.81 | CYP1A2 (0.44) | CYP1A2SIGMAR1TMEM97ADRA2AADRA2B | |
| SCHEMBL2110977 | 0.79 | CYP1A2 (0.45) | CYP1A2SIGMAR1TMEM97ADRA2AADRA2B | |
| SCHEMBL13970695 | 0.78 | MEN1 (0.44) | CYP1A2SIGMAR1TMEM97ADRA2AADRA2B | |
| SCHEMBL2889221 | 0.77 | PTGER2 (0.40) | CYP1A2SIGMAR1TMEM97ADRA2AADRA2B | |
| SCHEMBL2883235 | 0.76 | PTGER2 (0.38) | CYP1A2SIGMAR1TMEM97ADRA2AADRA2B | |
| SCHEMBL2887263 | 0.76 | PRMT5 (0.41) | — | |
| SCHEMBL2889094 | 0.74 | KDM4E (0.44) | CYP1A2SIGMAR1TMEM97ADRA2AADRA2B | |
| SCHEMBL2111860 | 0.73 | PTGER2 (0.45) | CYP1A2SIGMAR1TMEM97ADRA2AADRA2B | |
| SCHEMBL10199939 | 0.73 | SIGMAR1 (0.46) | CYP1A2SIGMAR1TMEM97ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2213675-B1 | PYRIDOOXAZEPINE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2013-08-14 | — | — | EP | disclosed |
| US-8329687-B2 | Pyridooxazepine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-12-11 | — | — | US | disclosed |
| US-20100286120-A1 | PYRIDOOXAZEPINE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | US | disclosed |
| EP-2213675-A1 | PYRIDOOXAZEPINE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-08-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286120-A1 | PYRIDOOXAZEPINE DERIVATIVE AND USE THEREOF | HTR2C, HTR2A, TPH2 | CYP1A2 152/4885SIGMAR1 257/4885TMEM97 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.