⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1680482 | 0.79 | — | — | |
| SCHEMBL7704422 | 0.78 | CYP1B1 (0.32) | — | |
| SCHEMBL29086344 | 0.78 | CYP1B1 (0.32) | — | |
| SCHEMBL654800 | 0.77 | — | — | |
| SCHEMBL1259823 | 0.74 | — | — | |
| SCHEMBL245783 | 0.74 | — | — | |
| SCHEMBL1680347 | 0.74 | — | — | |
| SCHEMBL735083 | 0.74 | — | — | |
| SCHEMBL16011600 | 0.74 | — | — | |
| SCHEMBL916382 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1093 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024104425-A1 | KRAS INHIBITOR COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | 广东东阳光药业股份有限公司 | 2024-05-23 | — | — | WO | claimed |
| CN-118047801-A | KRAS inhibitor compound, pharmaceutical composition and application thereof | 广东东阳光药业股份有限公司 | 2024-05-17 | — | — | CN | claimed |
| CN-108299532-B | Antiviral nucleoside analogue prodrug and composition and application thereof | 广东东阳光药业有限公司 | 2020-12-22 | — | — | CN | claimed |
| CN-108299532-A | A kind of antiviral nucleoside analogue prodrug and combinations thereof, purposes | 广东东阳光药业有限公司 | 2018-07-20 | — | — | CN | claimed |
| EP-1250323-B1 | Compounds having hypolipidemic and hypocholesterolemic activities, process for their preparation and pharmaceutical compositions containing them | CADILA HEALTHCARE LTD (IN) | 2014-01-01 | — | — | EP | claimed |
| CN-100577658-C | Quinazoline derivatives | ASTRAZENECA AB | 2010-01-06 | — | — | CN | claimed |
| EP-2091929-A1 | AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS | The European Molecular Biology Laboratory (DE) | 2009-08-26 | — | — | EP | claimed |
| CN-101421257-A | Agents that disrupt cellular replication and their use in inhibiting pathological conditions | EUROPEAN MOLECULAR BIOLOGY LAB EMBL (DE) | 2009-04-29 | — | — | CN | claimed |
| WO-2007107352-A1 | AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS | THE EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2007-09-27 | — | — | WO | claimed |
| US-20070225291-A1 | Substituted Pyrazinone Compounds for the Treatment of Inflammation | PFIZER INC. | 2007-09-27 | — | — | US | claimed |
| EP-0610451-A1 | ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1994-08-17 | — | — | EP | claimed |
| US-5330996-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1994-07-19 | — | — | US | claimed |
| US-5227401-A | ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | claimed |
| US-5223535-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | claimed |
| WO-1993009108-A1 | AMINO ACYL AMINO PROPARGYL DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | claimed |
| WO-1993009086-A1 | PROPARGYL GLYCINE AMINO PROPARGYL DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | claimed |
| WO-1993009087-A1 | ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | claimed |
| EP-0539976-A1 | Ethynyl-alanine-amino-diol compounds for treatment of hypertension | G.D. Searle & Co. (US) | 1993-05-05 | — | — | EP | claimed |
| CN-1059336-A | Anti-fungal triazole derivatives and preparation thereof and purposes | SANKYO CO (JP) | 1992-03-11 | — | — | CN | claimed |
| EP-0473387-A2 | Anti-fungal triazole derivatives, their preparation and uses | Sankyo Company Limited (JP) | 1992-03-04 | — | — | EP | claimed |