Ethyne

Ethyne

SCHEMBL28907752

C#C.N#Cc1cc2cc-2c1

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.40
ALB P02768 2/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
VCAM1 P19320 2/20 0.37
CLK4 Q9HAZ1 1/20 0.37
TSHR P16473 1/20 0.36
MMP3 P08254 1/20 0.35
GRM5 P41594 2/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP2A6 P11509 1/20 0.33
CA12 O43570 1/20 0.33
CA2 P00918 1/20 0.33
CA3 P07451 1/20 0.33
CA6 P23280 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
RXRA P19793 1/20 0.33
RXRG P48443 1/20 0.33
PGR P06401 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28895632 0.82 TTR (0.42) TTRALBMEN1KMT2AVCAM1
SCHEMBL24017200 0.80 MMP3 (0.58) TSHRMMP3ALDH1A1CYP2A6CA12
SCHEMBL1543177 0.78 TSHR (0.55) CLK4TSHRALDH1A1
Cyanide SCHEMBL11880265 0.76 TTR (0.46) TTRALBMEN1KMT2AVCAM1
SCHEMBL60145 0.75 TTR (0.50) TTRALBMEN1KMT2AVCAM1
SCHEMBL491404 0.75 AHR (0.48) TSHRMMP3GRM5ALDH1A1PGR
SCHEMBL13606452 0.75 GRM5 (0.53) GRM5PGR
SCHEMBL17775874 0.73 PTPN5 (0.49) MEN1KMT2ACLK4TSHRPGR
SCHEMBL18411439 0.73 GABRA1 (0.49) CLK4TSHRGRM5
SCHEMBL18411464 0.73 GABRA1 (0.49) CLK4TSHRGRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115286555-A Synthetic method of 3-alkynylselendole compound 温州医科大学 2022-11-04 CN disclosed