Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 14/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.49 |
| ▸ | EED | O75530 | 1/20 | 0.49 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.49 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.49 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.49 |
| ▸ | PRAP1 | Q96NZ9 | 2/20 | 0.46 |
| ▸ | EZH1 | Q92800 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30022084 | 1.00 | EZH2 (0.61) | EZH2HDAC6EEDRBBP4SUZ12 | |
| SCHEMBL28520970 | 0.89 | EZH2 (0.77) | EZH2HDAC6EEDRBBP4SUZ12 | |
| SCHEMBL30022137 | 0.89 | EZH2 (0.77) | EZH2HDAC6EEDRBBP4SUZ12 | |
| SCHEMBL28521908 | 0.78 | EZH2 (0.87) | EZH2HDAC6EEDRBBP4SUZ12 | |
| SCHEMBL28516505 | 0.76 | EZH2 (1.00) | EZH2HDAC6EEDRBBP4SUZ12 | |
| SCHEMBL19503400 | 0.76 | EZH2 (0.80) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19503402 | 0.75 | EZH2 (0.78) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL30021793 | 0.74 | EZH2 (0.51) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16935365 | 0.73 | EZH2 (0.92) | EZH2HDAC6EZH1 | |
| SCHEMBL16935285 | 0.73 | EZH2 (0.92) | EZH2HDAC6EZH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112341390-B | Compound for preparing targeted histone methyltransferase EZH2 covalent inhibitor and preparation method and application thereof | 四川大学 | 2022-08-23 | — | — | CN | disclosed |
| CN-112341390-A | Compound for preparing targeted histone methyltransferase EZH2 covalent inhibitor and preparation method and application thereof | 四川大学 | 2021-02-09 | — | — | CN | disclosed |