Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 4/20 | 0.45 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.45 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28525603 | 0.92 | IGF1R (0.44) | IGF1RCDK2PLK1PLK3PLK2 | |
| SCHEMBL21600942 | 0.83 | IGF1R (0.45) | IGF1RCDK2PLK1PLK3PLK2 | |
| SCHEMBL21600800 | 0.83 | JAK3 (0.48) | IGF1RTTKJAK3FGFR1FGFR2 | |
| SCHEMBL30379611 | 0.82 | FGFR1 (0.49) | IGF1RCDK2PLK1PTK2PIM1 | |
| SCHEMBL28532459 | 0.82 | FGFR1 (0.49) | IGF1RCDK2PLK1PTK2PIM1 | |
| SCHEMBL28953575 | 0.82 | CDK2 (0.50) | IGF1RCDK2PLK1PLK3PLK2 | |
| SCHEMBL28529195 | 0.82 | CDK2 (0.49) | IGF1RCDK2PLK1PLK3PLK2 | |
| SCHEMBL28542726 | 0.81 | FLT3 (0.59) | IGF1RCDK2PTK2PIM1JAK3 | |
| SCHEMBL30380211 | 0.81 | PTK2 (0.51) | IGF1RCDK2PTK2 | |
| SCHEMBL28533769 | 0.81 | ALK (0.56) | IGF1RPLK1PTK2PIM1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |