Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.64 |
| ▸ | KDR | P35968 | 10/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.64 |
| ▸ | FLT1 | P17948 | 7/20 | 0.64 |
| ▸ | FLT4 | P35916 | 7/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.64 |
| ▸ | TEK | Q02763 | 2/20 | 0.64 |
| ▸ | RET | P07949 | 2/20 | 0.64 |
| ▸ | KIF5B | P33176 | 2/20 | 0.64 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.64 |
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | CIT | O14578 | 1/20 | 0.64 |
| ▸ | GAK | O14976 | 1/20 | 0.64 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | STK10 | O94804 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21473616 | 0.83 | EGFR (0.69) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL21473603 | 0.83 | KDR (0.70) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL21473563 | 0.82 | EGFR (0.81) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL21473615 | 0.80 | KDR (0.72) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL21473617 | 0.80 | EGFR (0.70) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL8173228 | 0.80 | EGFR (0.82) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL30017782 | 0.79 | KDR (0.71) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL12534441 | 0.79 | EGFR (0.85) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL28959222 | 0.79 | EGFR (0.69) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL21473659 | 0.79 | EGFR (0.69) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110372666-B | Quinazoline compound as EGFR (epidermal growth factor receptor) triple mutation inhibitor and application thereof | 华东理工大学 | 2022-11-08 | — | — | CN | disclosed |