Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 8/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2891134 | 1.00 | KCNA5 (0.44) | KCNA5ABCB1ALDH1A1TAAR1IDO1 | |
| Maleic Acid SCHEMBL2891131 | 1.00 | KCNA5 (0.44) | KCNA5ABCB1ALDH1A1TAAR1IDO1 | |
| SCHEMBL2890974 | 0.93 | ABCB1 (0.47) | KCNA5ABCB1IDO1ABCC9 | |
| SCHEMBL2010363 | 0.93 | ABCB1 (0.47) | KCNA5ABCB1IDO1ABCC9 | |
| SCHEMBL2012518 | 0.86 | ABCB1 (0.43) | KCNA5ABCB1IDO1ABCC9 | |
| SCHEMBL2008673 | 0.86 | ABCB1 (0.43) | KCNA5ABCB1IDO1ABCC9 | |
| SCHEMBL2891815 | 0.86 | ABCB1 (0.43) | KCNA5ABCB1IDO1ABCC9 | |
| SCHEMBL2889297 | 0.86 | ABCB1 (0.43) | KCNA5ABCB1IDO1ABCC9 | |
| Fumaric Acid SCHEMBL2029427 | 0.84 | KCNA5 (0.40) | KCNA5ABCB1ALDH1A1TAAR1IDO1 | |
| SCHEMBL2889119 | 0.83 | KCNA5 (0.47) | KCNA5ABCB1ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652008-B2 | 2,2,7,9-tetramethyl-4-[(2-phenylethyl)amino]-3,4-dihydro-2H-pyrano[2,3-g]quinolin-3-ol; 3-hydroxy-2,2,9-trimethyl-4-[(2-phenylethyl)amino]-3,4-dihydro-2H-pyrano[2,3-g]quinolin-7-carbonitrile; have the prolongation effect on refractory period | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-01-26 | — | — | US | disclosed |