Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | LOX | P28300 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.41 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2486570 | 0.82 | NOTUM (0.49) | MAP4K4NOTUMIDO1LOXL2LOX | |
| SCHEMBL29889827 | 0.82 | NOTUM (0.49) | MAP4K4NOTUMIDO1LOXL2LOX | |
| SCHEMBL29594557 | 0.81 | METAP2 (0.44) | MAP4K4NOTUMIDO1LOXL2MKNK1 | |
| SCHEMBL25222544 | 0.81 | MAP4K4 (0.50) | MAP4K4NOTUMIDO1LOXL2LOX | |
| SCHEMBL30112165 | 0.81 | MAP4K4 (0.50) | MAP4K4NOTUMIDO1LOXL2LOX | |
| SCHEMBL3140455 | 0.77 | MAP4K4 (0.63) | MAP4K4MKNK1MKNK2TGFBR1 | |
| SCHEMBL29575679 | 0.77 | KCNH2 (0.53) | MAP4K4MKNK1MKNK2TGFBR1PDE10A | |
| SCHEMBL22322823 | 0.75 | IDO1 (0.56) | MAP4K4NOTUMIDO1LOXL2LOX | |
| SCHEMBL27785145 | 0.75 | POLB (0.51) | NOTUMIDO1LOXL2LOXPARP15 | |
| SCHEMBL28267323 | 0.75 | DHFR (0.51) | MAP4K4NOTUMIDO1LOXL2LOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115461120-A | Sulfonylimide compounds as NLRP3 modulators | 豪夫迈·罗氏有限公司 | 2022-12-09 | — | — | CN | disclosed |