Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23816211 | 0.96 | BTK (0.43) | BTKJAK2WNT3AHDAC4GPR119 | |
| SCHEMBL30063447 | 0.96 | BTK (0.43) | BTKJAK2WNT3AHDAC4GPR119 | |
| SCHEMBL26115894 | 0.83 | BTK (0.42) | BTKJAK2HDAC4GPR119JAK3 | |
| SCHEMBL30063492 | 0.81 | BTK (0.49) | BTKLCK | |
| SCHEMBL23816181 | 0.81 | BTK (0.49) | BTKLCK | |
| SCHEMBL28915495 | 0.80 | BTK (0.51) | BTKLCK | |
| SCHEMBL28915511 | 0.80 | BTK (0.44) | BTKJAK2WNT3AHDAC4GPR119 | |
| SCHEMBL29188564 | 0.79 | BTK (0.43) | BTKJAK2WNT3AHDAC4GPR119 | |
| SCHEMBL24801058 | 0.79 | BTK (0.41) | BTKJAK2WNT3AHDAC4GPR119 | |
| SCHEMBL23816550 | 0.78 | WNT3A (0.38) | BTKJAK2WNT3AGPR119JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115335376-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitor with E3 ligase ligand and methods of use thereof | 百济神州有限公司 | 2022-11-11 | — | — | CN | disclosed |