Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.45 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.45 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL722926 | 1.00 | LMNA (0.45) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL28778164 | 0.93 | LMNA (0.39) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Adipic Acid SCHEMBL906129 | 0.91 | LMNA (0.50) | LMNAALDH1A1SLC22A6TSHRFOLH1 | |
| Adipic Acid SCHEMBL29427201 | 0.91 | LMNA (0.50) | LMNAALDH1A1SLC22A6TSHRFOLH1 | |
| Glutarate SCHEMBL28487046 | 0.91 | SLC22A6 (0.50) | LMNAMAPK1SLC22A6TSHRNFKB1 | |
| Glutarate SCHEMBL9485824 | 0.91 | SLC22A6 (0.50) | LMNAMAPK1SLC22A6TSHRNFKB1 | |
| SCHEMBL27786269 | 0.89 | TSHR (0.36) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Octanedioate SCHEMBL1394807 | 0.89 | TSHR (0.52) | LMNAOR51E2ALDH1A1SLC22A6TSHR | |
| Azelaic Acid SCHEMBL28918234 | 0.89 | TSHR (0.52) | LMNAOR51E2ALDH1A1SLC22A6TSHR | |
| Octanedioate SCHEMBL6037661 | 0.89 | TSHR (0.52) | LMNAOR51E2ALDH1A1SLC22A6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109988314-B | Hyperbranched chitosan, and preparation method and application thereof | 大连民族大学 | 2021-07-02 | — | — | CN | disclosed |