Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | HCK | P08631 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.43 |
| ▸ | PRKDC | P78527 | 2/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.43 |
| ▸ | TFPI2 | P48307 | 2/20 | 0.42 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28917883 | 0.99 | KDR (0.43) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL28917639 | 0.90 | KDR (0.42) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL3839289 | 0.83 | TFPI2 (0.51) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL3043613 | 0.78 | PSMB1 (0.49) | KMT2AMEN1HTTKDM4EGAA | |
| SCHEMBL30230816 | 0.78 | TUBB1 (0.55) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL2266733 | 0.78 | TUBB1 (0.55) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL3834511 | 0.78 | HTR6 (0.44) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL16424238 | 0.78 | HRH3 (0.52) | KMT2AMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL28917884 | 0.77 | PSMB1 (0.47) | KMT2AMEN1HTTKDM4E | |
| SCHEMBL8533712 | 0.76 | PIK3CD (0.44) | KDRPIK3CDABL1EGFRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110229091-B | 1, 5-disubstituted indole derivatives with leukotriene A4 hydrolase inhibition effect and application thereof | 天津科技大学 | 2022-11-22 | — | — | CN | disclosed |